虽然医生知道哪些因素会增加患癌风险，但大多数癌症会发生于没有任何已知导致癌症的风险因素的人身上。可导致癌症风险增加的已知因素包括：多數癌症是自發性的（英語：sporadic），但是有些癌症還是與遺傳有關，通常遺傳到缺陷的腫瘤抑制基因時會有較顯著

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